Changes in Serum High-Molecular-Weight Adiponectin Levels in Critically Ill Children with Systemic Inflammatory Response Syndrome

Peteris Tretjakovs1, *, Linda Rautiainena2, Gita Krievina1, Antra Jurka1, Ilze Grope2, Dace Gardovska1
1 Department of Human Physiology and Biochemistry, Riga Stradins University, Riga, Latvia
2 Children's Clinical University Hospital, Riga, Latvia

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© Tretjakovs et al.; Licensee Bentham Open

open-access license: This is an open access article licensed under the terms of the Creative Commons Attribution-Non-Commercial 4.0 International Public License (CC BY-NC 4.0) (, which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited.

# Address correspondence to this author at the Department of Human Physiology and Biochemistry, Riga Stradins University, 16 Dzirciema street, Riga, LV-1007, Latvia; Tel: +371 26167125; E-mail:



The aim of the study was to evaluate the effect of the systemic inflammatory response syndrome (SIRS) on serum high-molecular-weight adiponectin (HMWA) levels.


Twelve children with SIRS were enrolled in this study at the intensive care unit (ICU). Twelve age and sex matched healthy subjects were selected as controls. Serum HMWA, interleukin-6 (IL-6), C-reactive protein (CRP), and procalcitonin (PCT) levels were determined after 2 hours and 24 hours, and on the day of discharge which was on the average 9.4 days after ICU admission.


2 hours after admission to the ICU, the patients had significantly decreased serum HMWA levels compared with healthy controls (P < .001). 24 hours after the admission, the patients did not have any significant changes in their HMWA levels, however on the day of discharge, on average 9.4 days after hospital admission, a significant increase was observed (P < .05). After the treatment, there was a decrease in serum PCT, IL-6 and CRP levels. The only variable that was decreased 24 hours after the ICU admission was PCT (P < .05). A negative correlation was found between serum HMWA and PCT levels, and between HMWA and CRP (P < .05 and P < .01), however no correlation was found between HMWA and IL-6.


In SIRS we observed a marked reduction in serum HMWA concentrations and a profound increase in IL-6, PCT, and CRP levels. A significant relationship between serum HMWA and PCR and CRP levels was evident.

Keywords: Adiponectin Levels, High-molecular-weight adiponectin, Pro-inflammatory biomarkers, Systemic inflammatory response syndrome.