RESEARCH ARTICLE

Changes in Serum High-Molecular-Weight Adiponectin Levels in Critically Ill Children with Systemic Inflammatory Response Syndrome

Open Medicine Journal 31 Aug 2016 RESEARCH ARTICLE DOI: 10.2174/1874220301603010166

Abstract

Background:

The aim of the study was to evaluate the effect of the systemic inflammatory response syndrome (SIRS) on serum high-molecular-weight adiponectin (HMWA) levels.

Method:

Twelve children with SIRS were enrolled in this study at the intensive care unit (ICU). Twelve age and sex matched healthy subjects were selected as controls. Serum HMWA, interleukin-6 (IL-6), C-reactive protein (CRP), and procalcitonin (PCT) levels were determined after 2 hours and 24 hours, and on the day of discharge which was on the average 9.4 days after ICU admission.

Results:

2 hours after admission to the ICU, the patients had significantly decreased serum HMWA levels compared with healthy controls (P < .001). 24 hours after the admission, the patients did not have any significant changes in their HMWA levels, however on the day of discharge, on average 9.4 days after hospital admission, a significant increase was observed (P < .05). After the treatment, there was a decrease in serum PCT, IL-6 and CRP levels. The only variable that was decreased 24 hours after the ICU admission was PCT (P < .05). A negative correlation was found between serum HMWA and PCT levels, and between HMWA and CRP (P < .05 and P < .01), however no correlation was found between HMWA and IL-6.

Conclusion:

In SIRS we observed a marked reduction in serum HMWA concentrations and a profound increase in IL-6, PCT, and CRP levels. A significant relationship between serum HMWA and PCR and CRP levels was evident.

Keywords: Adiponectin Levels, High-molecular-weight adiponectin, Pro-inflammatory biomarkers, Systemic inflammatory response syndrome.
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