Is There a Link Between Cholesterol Level and the Risk of Developing Depression?

Marlena Broncel*, Katarzyna Serejko-Banaś
Department of Internal Diseases and Clinical Pharmacology, Faculty of Military Medicine, Medical University of Lodz, Poland

Article Metrics

CrossRef Citations:
Total Statistics:

Full-Text HTML Views: 2935
Abstract HTML Views: 1434
PDF Downloads: 545
ePub Downloads: 474
Total Views/Downloads: 5388
Unique Statistics:

Full-Text HTML Views: 1242
Abstract HTML Views: 857
PDF Downloads: 394
ePub Downloads: 328
Total Views/Downloads: 2821

Creative Commons License
© Broncel and Serejko; Licensee Bentham Open

open-access license: This is an open access article licensed under the terms of the Creative Commons Attribution-Non-Commercial 4.0 International Public License (CC BY-NC 4.0) (, which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited.

* Address correspondence to this author at the Department of Internal Diseases and Clinical Pharmacology, Faculty of Military Medicine, Medical University of Lodz, Poland, WSS im. Bieganskiego, ul. Kniaziewicza 1/5 91-347 Łódź, Poland; Tel: +48 42 251 62 43; E-mail:


Depressive disorders and hypercholesterolemia are serious and common global problems. Many researchers have attempted to demonstrate association between concentration of the lipid fractions, depression as well as the rate of suicide, but the results are inconclusive. To overcome this lack of knowledge, we have summarized the studies concerning this relationship and published in recent years. All of articles included were published in peer reviewed journals and were identified through systematic query of PubMed with follow-up manual searches.

Concentrations of total cholesterol – TC, cholesterol – LDL-C, cholesterol - HDL-C other triglycerides and others atherogenic index and comorbidity with depressive disorders have been considered. While both positive and negative association between lipid fractions and depression have been shown in many studies, some data revealed no relationships between the two factors. In addition, we have also summarized the usage of statins and the occurrence of depressive disorders, and the results remain inconclusive.

In conclusion, our review did not reveal a clear relationship between lipid fractions and depression. Additional studies are needed as increased incidence of comorbidity between mood disorders and lipid disorders have been observed.

Keywords: Depression, Depressive Disorders, Lipids, Statins, Suicide.