Pathophisiological and Neuropharmacological Mechanisms Under- lying the Therapeutical Effects of Tianeptine
Fuad Lechin*, Bertha Van der Dijs
Identifiers and Pagination:Year: 2017
First Page: 9
Last Page: 12
Publisher ID: MEDJ-4-9
Article History:Received Date: 25/01/2017
Revision Received Date: 16/03/2017
Acceptance Date: 28/03/2017
Electronic publication date: 23/05/2017
Collection year: 2017
open-access license: This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 International Public License (CC-BY 4.0), a copy of which is available at: https://creativecommons.org/licenses/by/4.0/legalcode. This license permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Tianeptine, a drug that enhances rather than inhibits serotonin uptake by platelets and serotonergic axons, is able to act as an antidepressant and/or anti-stress drug.
The former effect should be attributed to its ability to reduce neural sympathetic over activity, whereas the latter to the interference by the drug to the hypothalamic stress cascade which includes corticotropin releasing factor + ACTH + cortisol secretion.
This singular mechanism should be taken into account when the drug is prescribed as a therapeutic agent.