REVIEW ARTICLE


Pathophisiological and Neuropharmacological Mechanisms Under- lying the Therapeutical Effects of Tianeptine



Fuad Lechin*, Bertha Van der Dijs
Department of Physiological Sciences, Section of Neuroendocrinology, Neuropharmacology and Neurochemistry, Instituto de Medicina Experimental, Universidad Central de Venezuela, Caracas, Venezuela


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© 2017 Lechin and Van der Dijs.

open-access license: This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 International Public License (CC-BY 4.0), a copy of which is available at: https://creativecommons.org/licenses/by/4.0/legalcode. This license permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

* Address correspondence to this author at the Department of Physiological Sciences, Section of Neuroendocrinology, Neuropharmacology and Neurochemistry, Instituto de Medicina Experimental, Universidad Central de Venezuela, Apartado 80983, Caracas 1080-A, Venezuela; Tel: 58 212 9610172; Fax: 58 212 9610172; E-mail: flechin828@gmail.com


Abstract

Background:

Tianeptine, a drug that enhances rather than inhibits serotonin uptake by platelets and serotonergic axons, is able to act as an antidepressant and/or anti-stress drug.

Methods:

The former effect should be attributed to its ability to reduce neural sympathetic over activity, whereas the latter to the interference by the drug to the hypothalamic stress cascade which includes corticotropin releasing factor + ACTH + cortisol secretion.

Conclusion:

This singular mechanism should be taken into account when the drug is prescribed as a therapeutic agent.

Key words : Tianeptine, Depression, Epinephrine, Norepinephrine, Stress, Corticotropin releasing factor.