Co-occurring Depression, Chronic Pain and Substance Use Disorders in People with Hepatitis C
Elizabeth Chereji1, Shira Kern1, Bret Fuller2, 3, Benjamin J. Morasco2, 3, Alissa Phelps2, Peter Hauser1, 4, 5, 6, *
Identifiers and Pagination:Year: 2016
Issue: Suppl 1: M5
First Page: 79
Last Page: 103
Publisher ID: MEDJ-3-79
Article History:Received Date: 6/2/2015
Revision Received Date: 20/3/2016
Acceptance Date: 11/6/2016
Electronic publication date: 29/07/2016
Collection year: 2016
open-access license: This is an open access article licensed under the terms of the Creative Commons Attribution-Non-Commercial 4.0 International Public License (CC BY-NC 4.0) (https://creativecommons.org/licenses/by-nc/4.0/legalcode), which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited.
Chronic infection with Hepatitis C virus (HCV) is common and can result in serious and sometimes fatal liver complications. The impact of HCV on the liver can be further complicated by medical and psychological comorbidities. Depression, substance use, and pain syndromes are frequent co-morbid conditions in people with HCV and diminish functioning, quality of life, and treatment compliance. Understanding the underlying biological mechanisms of these comorbid conditions within the context of HCV may help elucidate factors contributing to their co-occurrence, perhaps mediated via pro-inflammatory cytokines. The current review provides a synthesis of the literature on depression, substance use disorders and chronic pain in the presence of HCV. The review includes studies conducted with both veteran and civilian populations. The implications for assessment and antiviral treatment of HCV will be considered.