Current and Emerging Therapeutic Regimens for Patients with Chronic Hepatitis C Infection

Solaimani, Pejman; Hogan, Christopher; Chin, Matthew; Miranda, Juan L; Nguyen, Douglas L

Current and Emerging Therapeutic Regimens for Patients with Chronic Hepatitis C Infection

Pejman Solaimani¹, Christopher Hogan^{2, 3}, Matthew Chin^{2, 3}, Juan L Miranda⁴, Douglas L Nguyen^{2, 3, *}

¹ Department of Medicine, University of California-Irvine, Irvine, CA, United States

² Division of Gastroenterology and Hepatology, University of California-Irvine, Irvine, CA, United States

³ Division of Gastroenterology and Hepatology, VA Long Beach Health Care System, Irvine, CA, United States

⁴ Mental Health, Long Beach VA Medical Center, Irvine, CA, United States

Article Information

Identifiers and Pagination:

Year: 2016
Volume: 3
Issue: Suppl 1: M3
First Page: 58
Last Page: 69
Publisher ID: MEDJ-3-58
DOI: 10.2174/1874220301603010058

Article History:

Received Date: 12/01/2014
Revision Received Date: 12/06/2015
Acceptance Date: 25/06/2015
Electronic publication date: 29/07/2016
Collection year: 2016

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© Solaimani et al.; Licensee Bentham Open.

open-access license: This is an open access article licensed under the terms of the Creative Commons Attribution-Non-Commercial 4.0 International Public License (CC BY-NC 4.0) (https://creativecommons.org/licenses/by-nc/4.0/legalcode), which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited.

^* Address correspondence to this author at the Department of Medicine, UC Irvine School of Medicine, 333 City Blvd. West, Suite 400 Orange, CA 92868, USA; Tel: 714-456-6745; Fax: 714-456-7753; E-mail: douglaln@uci.edu

With 5.2 million people living with Hepatitis C, it is the most common blood-borne infection in the United States. Untreated chronic HCV infection may result in adverse consequences such as cirrhosis, portal hypertension, hepatic failure and hepatocellular carcinoma. Previously approved treatments include Pegylated-interferon alpha-2a/2b plus ribavirin, Boceprevir and Telaprevir. Recently approved medications include Sofosbuvir (SOF), Simeprevir (SMV), Ledispavir-Sofosbuvir (Harvoni®) and Ombitasvir-paritaprevir-ritonavir with dasabuvir tablets (Viekira Pak). Here we review the literature describing the current and emerging therapies for chronic hepatitis C.

Keywords: Chronic, Direct acting antiviral agents, Hepatitis C, Treatment.

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RESEARCH ARTICLE

Current and Emerging Therapeutic Regimens for Patients with Chronic Hepatitis C Infection

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Abstract

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