Complications of Acute Kidney Injury in COVID-19 Patients: A Systematic Review

2 See the PRISMA 2020 for Abstracts checklist


INTRODUCTION
-Rationale 3 Describe the rationale for the review in the context of existing knowledge.3 Objectives 4 Provide an explicit statement of the objective(s) or question(s) the review addresses.3

METHODS -
Eligibility criteria 5 Specify the inclusion and exclusion criteria for the review and how studies were grouped for the syntheses.

4
Information sources 6 Specify all databases, registers, websites, organisations, reference lists and other sources searched or consulted to identify studies.Specify the date when each source was last searched or consulted.

4
Search strategy 7 Present the full search strategies for all databases, registers and websites, including any filters and limits used.

4
Selection process 8 Specify the methods used to decide whether a study met the inclusion criteria of the review, including how many reviewers screened each record and each report retrieved, whether they worked independently, and if applicable, details of automation tools used in the process.

4
Data collection process 9 Specify the methods used to collect data from reports, including how many reviewers collected data from each report, whether they worked independently, any processes for obtaining or confirming data from study investigators, and if applicable, details of automation tools used in the process.

Data items 10a
List and define all outcomes for which data were sought.Specify whether all results that were compatible with each outcome domain in each study were sought (e.g. for all measures, time points, analyses), and if not, the methods used to decide which results to collect.

10b
List and define all other variables for which data were sought (e.g.participant and intervention characteristics, funding sources).Describe any assumptions made about any missing or unclear information. 4 Study risk of bias assessment 11 Specify the methods used to assess risk of bias in the included studies, including details of the tool(s) used, how many reviewers assessed each study and whether they worked independently, and if applicable, details of automation tools used in the process.

4
Effect measures 12 Specify for each outcome the effect measure(s) (e.g.risk ratio, mean difference) used in the synthesis or presentation of results.

Location
where item is reported

Synthesis methods 13a
Describe the processes used to decide which studies were eligible for each synthesis (e.g.tabulating the study intervention characteristics and comparing against the planned groups for each synthesis (item #5)).

13b
Describe any methods required to prepare the data for presentation or synthesis, such as handling of missing summary statistics, or data conversions.

13c
Describe any methods used to tabulate or visually display results of individual studies and syntheses.PRISMA 13d Describe any methods used to synthesize results and provide a rationale for the choice(s).If metaanalysis was performed, describe the model(s), method(s) to identify the presence and extent of statistical heterogeneity, and software package(s) used.

Excel sheet 13e
Describe any methods used to explore possible causes of heterogeneity among study results (e.g.subgroup analysis, meta-regression).

13f
Describe any sensitivity analyses conducted to assess robustness of the synthesized results.4 Reporting bias assessment 14 Describe any methods used to assess risk of bias due to missing results in a synthesis (arising from reporting biases). 4 Certainty assessment 15 Describe any methods used to assess certainty (or confidence) in the body of evidence for an outcome.4

Study selection 16a
Describe the results of the search and selection process, from the number of records identified in the search to the number of studies included in the review, ideally using a flow diagram.

16b
Cite studies that might appear to meet the inclusion criteria, but which were excluded, and explain why they were excluded. 5

Study characteristics 17
Cite each included study and present its characteristics.14,15,16

Risk of bias in studies 18
Present assessments of risk of bias for each included study.5

Results of individual studies 19
For all outcomes, present, for each study: (a) summary statistics for each group (where appropriate) and (b) an effect estimate and its precision (e.g.confidence/credible interval), ideally using structured tables or plots.17

Results of syntheses 20a
For each synthesis, briefly summarise the characteristics and risk of bias among contributing studies.